- JAMA Psychiatry Peer Reviewers in 2024on May 7, 2025 at 12:00 am
We sincerely thank the 651 peer reviewers who completed manuscript reviews for JAMA Psychiatry in 2024.
- Female Physician Suicide Compared to the General Populationon May 1, 2025 at 12:00 am
US physicians’ elevated risk for depression has been well established in the past decade—however, the risk of physician suicide relative to the general public remains unclear. In this issue of JAMA Psychiatry, Makhija and colleagues use data from 97 915 US suicides from 2017 to 2021, drawn from the US National Violent Death Reporting System, to estimate sex-specific suicide incidence rates among physicians and the general population. The authors’ findings indicate that rates of suicide are higher among female physicians and lower among male physicians compared to sex-matched nonphysicians in the general population.
- Evidence-Based Practicing in Mental Healthon May 1, 2025 at 12:00 am
This Viewpoint explores the shift from the process-oriented concept of evidence-based practicing toward the development and distribution of evidence-based practices within the sphere of mental health care.
- Accelerated Theta-Burst Stimulation for Treatment-Resistant Depressionon May 1, 2025 at 12:00 am
The TTT (Triple TBS Thirty-Minute Interval) randomized clinical trial is a triple-blinded, sham-controlled study conducted among adults with treatment-resistant depression (TRD) evaluating the efficacy and safety of a pragmatic accelerated theta-burst stimulation protocol for TRD.
- Differences in Blood Leukocyte Subpopulations in Schizophreniaon May 1, 2025 at 12:00 am
This meta-analysis examines reports of blood leukocyte subpopulations in patients with schizophrenia vs healthy controls, examining disease- and treatment-related differences and potential confounders, to provide evidence to support or challenge the immune hypothesis of schizophrenia.
Personalized Medicine in Psychiatry Personalized Medicine in Psychiatry RSS feed.
- Home-based transcranial direct current stimulation (tDCS) in major depressive disorder: Enhanced network synchronization with active relative to sham and deep learning-based predictors of remissionby Wenyi Xiao, Jijomon C. Moncy, Rachel D. Woodham, Sudhakar Selvaraj, Nahed Lajmi, Harriet Hobday, Gabrielle Sheehan, Ali-Reza Ghazi-Noori, Peter J. Lagerberg, Rodrigo Machado-Vieira, Jair C. Soares, Allan H. Young, Cynthia H.Y. Fu on March 7, 2025 at 12:00 am
Major depressive disorder (MDD) is a common and debilitating mental health disorder, characterized by persistent feelings of a low mood or inability to experience pleasure that is associated with a diminished interest in daily activities and changes in neurovegetative symptoms [1]. MDD is a heterogenous disorder, in which the remission rate is around 30–40 % following the initial medication trial and about 50–55 % after a subsequent trial, and there can be a lengthy process of trial and error to identify the optimal treatment [2,3].
- Gene therapy for obsessive–compulsive disorder: Basic research and clinical prospectsby Fatemeh Bamarinejad, Marzieh Shokoohi, Atefeh Bamarinejad on February 26, 2025 at 12:00 am
Obsessive-Compulsive Disorder (OCD) is a prevalent psychiatric condition known for its resistance to conventional treatments. Despite available pharmacological and psychotherapeutic interventions, a significant number of patients do not respond adequately to these approaches. Recent genome-wide association studies (GWAS) have identified genetic links to OCD, sparking interest in exploring gene therapy as an alternative treatment method.
- The burden of chronic anxiety and depression symptomatology on 20-year cardiovascular disease incidence: The ATTICA study (2002–2022)by Vasiliki C. Baourda, Christina Chrysohoou, Fotios Barkas, Evrydiki Kravvariti, Evangelos Liberopoulos, Konstantinos Tsioufis, Petros P. Sfikakis, Christos Pitsavos, Demosthenes Panagiotakos on February 26, 2025 at 12:00 am
Despite the significant improvements in global health over the last decades, heart disease, and psychological disorders remain of the most significant global health burdens that are associated with increased mortality and morbidity [1]. Many observational studies and meta-analyses have already underlined that depression and anxiety are associated with higher risk of cardiovascular disease (CVD) [2,3,4,45]. Growing evidence indicates a complex path between symptoms of depression, anxiety and the onset and mortality of CVD [5,6,7,8,9,10,45].
- Mindfulness-based cognitive therapy as an adjunctive treatment for treatment-resistant depression: A systematic reviewby Michele F Rodrigues, Larissa Junkes, Jose Appolinario, Antonio E Nardi on January 28, 2025 at 12:00 am
Treatment-Resistant Depression (TRD) represents a significant challenge in the clinical management of depression, affecting approximately 20 % to 30 % of patients with Major Depressive Disorder (MDD) [1,2]. TRD is generally defined as the failure to achieve remission after two or more adequate trials of antidepressants from different classes, at appropriate doses and durations, often also including non-response to evidence-based psychotherapies such as Cognitive Behavioral Therapy (CBT) [3,4]. This condition leads to substantial negative impacts on patients’ quality of life, daily functioning, and increases the risk of relapse and suicide [5].
- The role of meta-cognitive and emotional beliefs, and negative repetitive thinking in the relationship between emotional abuse and psychological distress in psychiatric outpatients: A serial multiple mediation modelby Mehdi Rezaei, Hadi Samadieh, Mohammad Mahdi Shariat Bagheri, Ezatolah Ghadamour on December 3, 2024 at 12:00 am
Psychological distress is mainly characterized as a state of emotional suffering that is accompanied by symptoms of depression, anxiety, anger, insomnia, cognitive problems, and somatization [1,2]. In other words, psychological distress is an undifferentiated group of symptoms that range from symptoms of depression and anxiety to behavioral problems, functional impairment, and personality traits [1]. Although psychological distress is defined as a non-specific mental health problem, it is characterized by symptoms of depression and anxiety and they are not entirely independent [3,4].
